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Image Search Results
Journal: American Journal of Physiology - Cell Physiology
Article Title: Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells
doi: 10.1152/ajpcell.00250.2016
Figure Lengend Snippet: Schematic presentation that demonstrates a link between purinergic receptor-mediated signaling and cellular metabolic pathways. Stimulation of purinergic receptors (presumably P2 subtype and, to a lesser extent, P1 subtype) by extracellular ATP, MeSADP, and adenosine (Ado) results in activation of PI3K/Akt pathway, upregulation of glucose transporter-1 (GLUT-1), as well as metabolic enzymes involved in glycolysis [hexokinase (HK) phosphofructokinase (PFK) B3, and lactate dehydrogenase (LDH)] and oxidative phosphorylation (OXPHOS) [pyruvate dehydrogenase (PDH)-E1α, COX IV, succinate dehydrogenase (SDH), and F 0 F 1 ATP synthase]. As a result, activation of glycolysis and OXPHOS, and increase in mitochondrial Ca 2+ , can be observed in VVEC. P2R, P2 purinergic receptors; P1R, P1 purinergic receptors. Solid arrows indicate functional connection between proteins and pathways, dashed arrows indicate a cross talk between pathways, and dotted arrows indicate transport glucose and ATP and functional connection between Akt and its target proteins.
Article Snippet: Cells were incubated with
Techniques: Activation Assay, Functional Assay